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POLYNUCLEOTIDES
Polynucleotides are a regenerative skin treatment that works at a cellular level. Made from highly purified DNA fragments, they help the skin repair itself, improving hydration, elasticity, texture and firmness over a course of treatments.
At Ampika's Aesthetics in Marylebone, London and Hale, Cheshire, we use polynucleotides for the under-eyes, face, neck, chest and hands. They are especially popular for dark circles, crepey under-eye skin, fine lines, acne scarring and dull, tired skin.
TREATMENT TIME
About 30 minutes
CONSULTATION FIRST
Your practitioner will assess your skin and medical history first
DOWNTIME
Small bumps and mild redness for 24 to 48 hours
RESULTS
Skin improves gradually over a course of 3 sessions

ABOUT THE TREATMENT
As we age, the skin's ability to repair itself slows down. Collagen and elastin decline, the skin barrier weakens and the skin becomes thinner, drier and less elastic. The delicate under-eye area often shows this first, with hollows, dark circles and crepey skin. Polynucleotides are purified DNA fragments, usually derived from salmon, that are very similar to human DNA. When injected into the skin, they support the cells responsible for repair and regeneration. Rather than filling or freezing, they improve the health of the skin itself. The result is skin that looks brighter, firmer, smoother and more resilient, with a natural improvement that keeps building over the weeks after treatment.
Why Choose Ampika's Aesthetics
• Advanced regenerative skin treatment
• Specialist technique for the delicate under-eye area
• Treatment for the face, neck, chest and hands
• Honest advice on courses and combination treatments
• Clinics in London, Hale and Cheshire
WHAT TO EXPECT
Your Consultation
Your practitioner will look at your skin, ask about your concerns, skincare and medical history, and explain the expected results, any risks and aftercare. Polynucleotides are not suitable if you have a fish or salmon allergy, so please tell us at your consultation.
Your Treatment
Numbing cream can be applied first. Polynucleotides are injected into the skin using a fine needle or cannula, in small amounts across the treatment area. The treatment itself takes around 15 to 20 minutes.
Your Course
We usually recommend a course of 3 sessions, 2 to 3 weeks apart, followed by maintenance every 6 to 9 months.
Who Is It Suitable For?
Polynucleotides suit adults who want to improve skin quality, brighten the under-eyes, soften fine lines or improve acne scarring and texture. They are a good option for sensitive skin and for people who want natural results without changing their features. They are not suitable if you are allergic to fish or salmon, during pregnancy or breastfeeding, or if you have an active skin infection in the area. Results vary from person to person.
How Polynucleotides Work
Polynucleotides are chains of nucleotides, the building blocks of DNA. Once placed in the skin, they encourage fibroblasts, the cells that make collagen and elastin, to work more effectively. They also attract water, which deeply hydrates the skin, and they have an anti-inflammatory effect that helps calm and repair damaged tissue.
Because they support the skin's own repair processes, results build gradually over the course of treatments and continue to improve for several weeks after your final session.

Areas We Treat
Polynucleotides can be used wherever the skin needs repair, hydration and renewed firmness.

Under-Eyes
Our most requested area. Polynucleotides brighten dark circles, improve crepey skin and soften fine lines in the delicate under-eye area, where many other treatments are not suitable.

Face
Improves overall skin quality, hydration and firmness, giving the face a healthier, more radiant look.

Acne Scarring and Texture
Supports skin repair to improve uneven texture, enlarged pores and the look of acne scars, and works well alongside laser treatments.

Neck
Targets crepey skin and fine neck lines, improving firmness and smoothness.

Chest
Improves sun-damaged, crepey skin and fine lines on the décolletage.

Hands
Restores hydration and improves thin, crepey skin on the backs of the hands.
Benefits of Polynucleotides
A natural, regenerative way to improve your skin from within.
• Brightens dark circles and crepey under-eye skin
• Stimulates collagen and elastin production
• Improves skin texture, tone and firmness
• Softens fine lines and early wrinkles
• Helps improve the look of acne scarring
• Calms redness and supports a weakened skin barrier
• Natural results with no change to your features
TREATMENT PRICES
Choose your clinic below to see prices and book online
Results and How Long They Last
You may notice your skin feels more hydrated within a couple of weeks of your first session. The main improvement in brightness, texture and firmness builds over your course of 3 sessions and continues for several weeks afterwards. Results typically last 6 to 9 months, and maintenance sessions help keep them.
Results vary from person to person.
Aftercare
• Avoid make-up for 12 hours
• Avoid exercise, alcohol, saunas and steam rooms for 24 hours
• Do not massage or rub the treated area
• Avoid facials, peels and laser treatments for 2 weeks
• Use SPF daily and keep your skin well hydrated
Repair and Renew Your Skin
A regenerative treatment that helps your skin look healthier, brighter and firmer, naturally.
Book your polynucleotide treatment at our Marylebone or Hale clinic.





